Research Associate/Sr. Research Associate, In vivo tumor immunology

Company Background
Catamaran Bio is developing novel, off-the-shelf CAR-NK cell therapies designed to treat a broad range of cancers, including solid tumors. Our proprietary capabilities enable us to harness the natural cancer-fighting properties of NK cells and enhance and tailor their effectiveness with the power of synthetic biology and innovative non-viral cell engineering. We are using our TAILWIND™ Platform, an integrated suite of technologies, to specifically address the end-to-end methods of engineering, processing and manufacturing NK cells and rapidly advance our pipeline of CAR-NK cell therapy programs. Catamaran is backed by leading financial and corporate investors, including SV Health Investors, Sofinnova Partners, Lightstone Ventures, Takeda Ventures and Astellas Venture Management.

Job Summary
Catamaran Bio is seeking a highly motivated, experienced, and creative individual with expertise in mouse in vivo tumor efficacy studies to contribute to our research efforts to advance our best-in-class Immune Cell Therapies for Oncology. This individual will be responsible for carrying out in vivo pharmacology studies, through preclinical studies to IND submission.  This position is an exciting opportunity to work with talented scientists within a dynamic start-up environment in the Cambridge, MA biotech ecosystem.

Job Responsibilities

  • Perform immuno-oncology preclinical anti-tumor efficacy studies using adoptive transfer of NK cells for target validation, candidate selection, and IND-enabling studies
  • Run xenograft mouse studies to perform model development, anti-tumor efficacy, and PK/PD studies in conjunction with necropsy/tissue/blood collection across multiple projects with delivery of high-quality data
  • Prepare primary immune cells for in vivo dosing and perform cell culture with immortalized cell lines
  • Contribute to study designs
  • Meticulously execute on bench work, analyze data, troubleshoot and communicate findings
  • Provide data updates and technical expertise at project team meetings
  • Work collaboratively with internal teams
  • Contribute to report writing and documentation for regulatory and IP filings
  • Bring enthusiasm and a strong work ethic to the team setting using strong interpersonal skills and collaboration in fast paced environment
  • Contribute to building a positive, team-oriented biotech culture


Education, Experience and Qualifications

  • BS/MS with 0-2 years (RA level) or 2-4 years (SRA level) of relevant academic or industry experience
  • Clearly demonstrated experience with xenograft anti-tumor efficacy studies is required
  • Preference for experience with immune cell-based therapies such as T cells or NK cells
  • Expertise with animal handling, IV and IP dosing, adoptive cell transfer, and tissue harvesting and analysis
  • Proficiency in cell culture, passaging and harvesting cells for tumor implant is desired
  • Proficiency in utilizing software such as GraphPad Prism, electronic lab notebooks, Microsoft Office etc. for data analysis and figure generation is required
  • Ability to implement applicable regulations around animal care/safety/handling desired
  • Experience working in project teams
  • Technical rigor with attention to detail and experience in execution and analysis of experiments
  • Strong analytical, troubleshooting and excellent communication skills, highly organized with flawless record keeping and multi-tasking abilities
  • Highly collaborative working style, passion for immuno-oncology, and ability to adapt in a fast paced, rapidly developing environment

Please contact us at  or visit us at

Catamaran Bio is proud to be an equal opportunity workplace and is an affirmative action employer. We are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.