Scientist, Molecular Biology

Company Background

Catamaran Bio is developing novel, off-the-shelf CAR-NK cell therapies designed to treat a broad range of cancers, including solid tumors. Our proprietary capabilities enable us to harness the natural cancer-fighting properties of NK cells and enhance and tailor their effectiveness with the power of synthetic biology and innovative non-viral cell engineering. We are using our TAILWIND™ Platform, an integrated suite of technologies, to specifically address the end-to-end methods of engineering, processing and manufacturing NK cells and rapidly advance our pipeline of CAR-NK cell therapy programs. Catamaran is backed by leading financial and corporate investors, including SV Health Investors, Sofinnova Partners, Lightstone Ventures, Takeda Ventures and Astellas Venture Management.

Job Summary

Catamaran Bio is seeking a highly motivated, experienced, and creative individual with expertise in Molecular and Synthetic Biology to be a key contributor to our discovery research efforts to advance our best-in-class Immune Cell Therapies for Oncology. This individual will be responsible for carrying out synthetic construct designs for viral and transposon delivery systems, managing relationships with CROs and providing a critical coordination point across multiple teams to advance the Catamaran pipeline of cell therapies.  This position is an exciting opportunity to work with talented scientists within a dynamic start-up environment in the Cambridge, MA biotech ecosystem.

Job Responsibilities

  • Utilize molecular biology knowledge to translate protein design into gene construct synthesis of Chimeric Antigen Receptor (CAR) and Switch Receptor expression constructs for CMC, Pipeline and Synthetic Immunology groups
  • Develop innovative molecular biology approaches to enhance the functionality of our cell therapy pipeline to advance drug candidates into pre-clinical testing
  • Create de-novo viral and non-viral human expression constructs
  • Interface with and manage interactions with Contract Research Organizations to supply research and CMC groups with high quality plasmid material
  • Maintain records of plasmid designs and inventory using Electronic Laboratory Notebook Software
  • Perform, troubleshoot, and analyze molecular cloning experiments to support company objectives
  • Establish and perform QC analyses on plasmid material using AGE, spectrophotometers or TapeStation analyzers
  • Contribute to report writing and documentation for regulatory and IP filings
  • Bring enthusiasm and a strong work ethic to the team setting using strong interpersonal skills and collaboration in fast paced environment
  • Contribute to building a positive, team-oriented biotech culture
  • Work with supervisor to design experiments, meticulously execute bench work, troubleshoot assays, analyze data, record data, and communicate findings
  • Work collaboratively with internal team members by coordinating across line functions all reagents and supporting material to deliver starting nucleic acid material in specified timeline
  • Present results at internal meetings

Education, Experience and Qualifications

  • BS or MS +3 years of industry experience, or Ph.D. in molecular biology, cell biology, biology, immunology, or equivalent/related disciplines
  • Extensive experience with molecular biology design software including SnapGene, Benchling, MacVector or similar programs
  • Experience designing and generating viral and/or transposon expression constructs
  • Demonstrated experience with molecular biology techniques (PCR, Gibson and Golden Gate cloning) and DNA/mRNA quality assessment is required
  • Proven ability to deliver protein design solutions for technically challenging synthetic biology problems
  • Proficiency in data analysis software including GraphPad Prism, electronic lab notebooks, Microsoft Office etc. for data analysis and figure generation is required
  • Ability to balance CRO and internal resources to solve problems and drive progress
  • Experience engineering cell lines and primary immune cells is a plus
  • Experience with multi-parameter flow cytometry is desired
  • Strong analytical and troubleshooting skills with flawless record keeping and multi-tasking abilities
  • Ability to quickly learn, and adapt in a fast paced, rapidly developing environment.
  • Self-motivated and able to work both independently and on collaborative teams
  • Excellent organization and communication skills

Please contact us at  or visit us at

 Catamaran Bio is proud to be an equal opportunity workplace and is an affirmative action employer. We are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.