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Senior Research Associate / Associate Scientist, In Vivo Pharmacology

Company Background

Catamaran Bio is developing novel, off-the-shelf CAR-NK cell therapies designed to treat a broad range of cancers, including solid tumors. Our proprietary capabilities enable us to harness the natural cancer-fighting properties of NK cells and enhance and tailor their effectiveness with the power of synthetic biology and innovative non-viral cell engineering. We are using our TAILWIND™ Platform, an integrated suite of technologies, to specifically address the end-to-end methods of engineering, processing and manufacturing NK cells and rapidly advance our pipeline of CAR-NK cell therapy programs. Catamaran is backed by leading financial and corporate investors, including SV Health Investors, Sofinnova Partners, Lightstone Ventures, Takeda Ventures and Astellas Venture Management.

Job Summary

Catamaran Bio is seeking a highly motivated, experienced, and creative individual with expertise in cancer immunology and cell therapy to be a key driver in our preclinical research efforts to advance our best-in-class Immune Cell Therapies for Oncology. This individual will be responsible for driving in vivo pharmacology studies, through preclinical studies to IND submission.  This position is an exciting opportunity to work with talented scientists within a dynamic start-up environment in the Cambridge, MA biotech ecosystem.

Job Responsibilities

  • Contribute to the design and implementation of Immuno-oncology preclinical efficacy experiments and PK/PD studies for proof of concept, candidate selection and IND enabling studies
  • Run adoptive transfer xenograft mouse models in conjunction with necropsy/tissue/blood collection across multiple projects with delivery of high-quality data
  • Prepare primary immune cells for in vivo dosing and perform cell culture with immortalized cell lines
  • Develop novel methodologies for ex vivo characterization of engineered NK cells, biomarker assessment, and pharmacodynamic characterization
  • Independently and collaboratively design experiments, meticulously execute on bench work, analyze data, troubleshoot and communicate findings
  • Represent the in vivo pharmacology function at project team meetings, providing data updates, plans, and critical thinking
  • Work collaboratively with internal and external industry and academic teams
  • Contribute to report writing and documentation for regulatory and IP filings
  • Present findings at internal and external meetings
  • Bring enthusiasm and a strong work ethic to the team setting using strong interpersonal skills and collaboration in fast paced environment
  • Contribute to building a positive, team-oriented biotech culture

Education, Experience and Qualifications

  • BS/MS with 5+ years of relevant academic or industry experience
  • Clearly demonstrated experience with xenograft anti-tumor efficacy studies is required
  • Preference for experience with immune cell-based therapies such as T cells or NK cells
  • Expertise with animal handling, IV, SC and IP dosing, adoptive cell transfer, and tissue harvesting and analysis
  • Proficiency in cell culture, passaging and harvesting cells for tumor implant is desired
  • Experience with multi-parameter flow cytometry is desired
  • Experience with the development and implementation of ex vivo assays to measure functional parameters of engineered human NK cells
  • Proficiency in utilizing software such as GraphPad Prism, electronic lab notebooks, Microsoft Office etc. for data analysis and figure generation is required
  • Ability to implement applicable regulations around animal care/safety/handling desired
  • Demonstrated experience working in cross-functional teams
  • Previous experience with IND submission a plus
  • Creativity, intellectual, and technical rigor with experience in design, execution, and analysis of experiments
  • Strong analytical, troubleshooting and excellent communication skills, highly organized with flawless record keeping and multi-tasking abilities
  • Highly collaborative working style, passion for immuno-oncology, and ability to adapt in a fast paced, rapidly developing environment

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Catamaran Bio is proud to be an equal opportunity workplace and is an affirmative action employer. We are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.