Job Summary
The Cell Process Team is seeking a talented, diligent, and collaborative scientist to lead cell expansion process activities for the advancement of our best-in-class CAR-NK Cell Therapies for Oncology and other diseases. Cell Process works to ingeniously solve the challenges associated with the allogeneic manufacture of CAR-NK cell therapies including cell isolation/enrichment; cell engineering and gene editing; and cell expansion. They will be responsible for the design of a clinical-scale bioreactor process design for the expansion of clinical CAR-NK candidates, design and execution of cell-based assays for in-process characterization, and technical process transfer to internal and external manufacturing sites in support of Phase 1 clinical activities.
The ideal candidate is a self-motivated and technically competent process development scientist or engineer with hands-on experience in bioreactor design and control, who is excited to join a small, fast-paced team with a “can-do” attitude to drive forward our new cell therapy platform. This is a unique opportunity to realize the promise of allogeneic cell therapy manufacturing paradigms and bring the TAILWIND platform to life at a clinical scale.
Job Responsibilities
- Plan and execute experiments independently and collaboratively in cross-functional teams, to drive bioprocess development for CAR-NK cell therapies
- Perform in-depth analyses of cell biology and functions using a variety of cell-based assays and analytical methods
- Analyze and interpret data, and scale-up bioprocesses to support company-wide activities including cell engineering research and cell production
- Meticulously maintain records, generate reports, records, and documents for IP and regulatory filings
- Present results to scientific team and management as well as external meetings
- Actively contribute to building a positive, team-oriented, startup biotech culture; participate in the active exchange and challenge of scientific ideas
Education, Experience, and Qualifications
- Bachelors degree + 4 years of experience, Master’s degree + 2 years of experience, or Ph.D. in chemical engineering, immunology, biology, synthetic biology, chemical biology, biochemistry, pharmaceutical sciences, bioengineering, or equivalent/related disciplines
- Excellent understanding and technical skills with demonstrated experiences (academia or industry) in bioreactor design and control, scale-up parameters, scale-down models, and other experience in cell process development, process analytics, and immune cell assays
- Demonstrated experiences in working with bench-scale (2-20L) or clinical-scale (20L+) bioreactor systems bioreactor modeling, scale-up, scale-down, is highly preferred
- Excellent communication and presentation skills, capable of conveying complex biological data to non-experts
- Attention to detail and demonstrated ability in multi-tasking and thriving in teams with diverse technical expertise
- Experience in NK cells, electroporation, and transposon systems a plus
- Experience in directly or indirectly leading or managing teams is a plus
- Experience in publishing and/or presenting in public scientific forums (papers, posters, conference talks) is a plus
Please contact us at opportunities@catamaranbio.com or visit us at www.catamaranbio.com
Catamaran Bio is proud to be an equal opportunity workplace and is an affirmative action employer. We are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.
Job Summary
The Cell Process Team is seeking a talented, diligent, and collaborative research associate to execute and design cell expansion process activities for the advancement of our best-in-class CAR-NK Cell Therapies for Oncology and other diseases. Cell Process works to ingeniously solve the challenges associated with the allogeneic manufacture of CAR-NK cell therapies including cell isolation/enrichment; cell engineering and gene editing; and cell expansion. They will be responsible for the operation of a clinical-scale bioreactor process design for the expansion of clinical CAR-NK candidates, execution of cell-based assays for in-process characterization, and technical process transfer to internal and external manufacturing sites in support of Phase 1 clinical activities.
The ideal candidate is a self-motivated and technically competent process development scientist or engineer with an interest in bioreactor design and control, who is excited to join a small, fast-paced team with a “can-do” attitude to drive forward our new cell therapy platform. This is a unique opportunity to realize the promise of allogeneic cell therapy manufacturing paradigms and bring the TAILWIND platform to life at a clinical scale.
Job Responsibilities
- Execute experiments under supervision and independently in cross-functional teams, to drive bioprocess development for CAR-NK cell therapies
- Perform analyses of cell biology and functions using a variety of cell-based assays and analytical methods
- Analyze and interpret data to support company-wide activities including cell engineering research and cell production
- Meticulously maintain records, generate reports, records, and documents for IP and regulatory filings
- Present results to scientific team and management as well as external meetings
- Actively contribute to building a positive, team-oriented, startup biotech culture; participate in the active exchange and challenge of scientific ideas
Education, Experience, and Qualifications
- Bachelors or master’s degree in chemical engineering, immunology, biology, synthetic biology, chemical biology, biochemistry, pharmaceutical sciences, bioengineering, or equivalent/related disciplines
- 0-2 years’ experience in industry or academia
- Demonstrated understanding and technical skills in one or more of the following: primary human immune cell culture; bioreactor design and control; scale-up parameters; scale-down models; cryopreservation; buffer-exchange processes; fill-finish operations; and other experience in cell process development
- Excellent communication and presentation skills, capable of conveying complex biological data to non-experts
- Attention to detail and demonstrated ability in multi-tasking and thriving in teams with diverse technical expertise
- Highly preferred but non-essential qualifications:
- Experiences in cell therapy
- Experience in flow cytometry, multiplex analysis, and in vitro assessment of immune cells
- Experience in NK cells, electroporation, and transposon systems
- Experience in publishing and/or presenting in public scientific forums (papers, posters, conference talks)
Please contact us at opportunities@catamaranbio.com or visit us at www.catamaranbio.com
Catamaran Bio is proud to be an equal opportunity workplace and is an affirmative action employer. We are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.
Job Summary
Catamaran is seeking a diligent, motivated, and collaborative Research Associate or Senior Research Associate to run cell-based assays to help advance our Immune Cell Therapies to the clinic. This position is focused on cell therapy product characterization and will play a key role in the design and execution of assays supporting Process Development and regulatory filings. The ideal candidate is excited to develop new medicines for cancer, technically competent, and has significant experience with cell and molecular biology techniques, especially involving cell-based assays in 96 well plate format. The strong desire to learn and positive collaborative attitude are more important than experience in any specific method.
Job Responsibilities
- Maintain primary cultures of NK and target cells in a highly reproducible fashion
- Perform, and report on analytical assays, such as flow cytometry, IncuCyte, MSD/Luminex, cytotoxicity, qPCR/ddPCR, and nucleic acid preparation
- Work in close collaboration with platform teams, as well as Contract Research and Manufacturing Organizations to review data
- Maintain stocks of critical materials and contribute to basic lab and device maintenance
- Meticulously maintain records and documents for IP and regulatory filings
Education, Experience and Qualifications
- 6+ years, or MS with 4+ years of relevant experience in an academic or biotech/pharma setting
- Experience in gene/cell therapy or cell engineering is a plus
- Facility with software such as MS Office, FlowJo/FCS Express, JMP/GraphPad
- Ability to work independently, multitask, and meet deadlines in a rapidly changing environment, all with a team-oriented positive attitude
- Excellent organization and communication skills
Please contact us at opportunities@catamaranbio.com or visit us at www.catamaranbio.com
Catamaran Bio is proud to be an equal opportunity workplace and is an affirmative action employer. We are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.
Job Summary
The Director/Senior Director, External CDMO Manufacturing, reporting to the VP of Technical Operations and Manufacturing,will be responsible for managing activities related to the GMP production of early and late phase clinical materials produced at contract development and manufacturing organizations (CDMOs) for Catamaran’s in-house allogeneic CAR-NK cell therapy programs. This role will be responsible for working with internal and CDMO staff for the oversight and coordination of activities related to scheduling, manufacturing, quality, finances, supply chain and regulatory. They will act as primary relationship manager and point of contact with the CDMO(s) for cell therapy manufacturing while working closely withinternal Catamaran staff.
Job Responsibilities
- Developing timelines, budgets and coordinating execution of activities for all elements related to the GMP production, testing and fill finish of products manufactured at CDMO(s)
- Collaborating with Process Development and Analytical Development groups to ensure successful transfer of Catamaran’s manufacturing processes and analytical assays to the CDMO(s)
- Collaborating with external vendors and Catamaran’s Finance department to ensure critical raw materials and reagents are made available at the CDMOs to ensure timely execution of clinical product campaigns
- Leading and facilitating meetings between Catamaran and the CDMO(s) project team members.
- Coordinating the generation, review, execution and completion of scope of work documents, corresponding purchase orders, invoicing and any necessary change orders
- Tracking project activities, deliverables, and completion relative to budgets and Catamaran’s objectives
- Independently managing reviews of batch records and in-process results
- Assisting in generating technical reports and tech transfer documents
- Writing/revising SOPs and batch records as needed.
- Collaborating with Clinical Operations to ensure that cell products are available for clinical trials.
Education, Qualifications & Experience
- Degree in Biology or Life Sciences, bachelor’s degree/8 years’ experience or Master’s degree/5 years of relevant industry experience
- Strong understanding of cGMPs including change control, CAPAs, lot release and validation
- Highly organized and detailed oriented
- At least 5 years of project management or site management experience for cell/gene therapy programs
- Extensive experience in all aspects of project management including working with tools such as Microsoft Project and Smartsheet, creating trackers, dashboards, and other reporting tools
- Excellent communication skills
Please contact us at opportunities@catamaranbio.com or visit us at www.catamaranbio.com
Catamaran Bio is proud to be an equal opportunity workplace and is an affirmative action employer. We are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.
Company Background
Catamaran Bio is developing novel, off-the-shelf CAR-NK cell therapies designed to treat a broad range of cancers, including solid tumors. Our proprietary capabilities enable us to harness the natural cancer-fighting properties of NK cells and enhance and tailor their effectiveness with the power of synthetic biology and innovative non-viral cell engineering. We are using our TAILWIND™ Platform, an integrated suite of technologies, to specifically address the end-to-end methods of engineering, processing and manufacturing NK cells and rapidly advance our pipeline of CAR-NK cell therapy programs. Catamaran is backed by leading financial and corporate investors, including SV Health Investors, Sofinnova Partners, Lightstone Ventures, Takeda Ventures and Astellas Venture Management.
Job Summary
Catamaran Bio is seeking a highly motivated, experienced, and creative individual with expertise in cancer immunology and cell therapy to be a key contributor to our preclinical research efforts to advance our best-in-class Immune Cell Therapies for Oncology. This individual will be responsible for carrying out cell engineering and in vitro studies, providing a critical coordination point across multiple teams to advance the Catamaran pipeline of cell therapies. This position is an exciting opportunity to work with talented scientists within a dynamic start-up environment in the Cambridge, MA biotech ecosystem.
Job Responsibilities
- Isolate immune cells from human tissue sources for ex vivo engineering, characterization, functional assessment, and in vivo adoptive transfer studies
- Independently contribute to the design, development, and execution of in vitro and ex vivo cell-based assays using cell lines and human primary cells
- Perform cellular and molecular assays, including multi-color flow cytometry, cytotoxicity, and cytokine release
- Perform human cell culture, including transformed cell lines and primary immune cells
- Work with supervisor on assay development and troubleshooting, data analysis, and communicate findings at internal meetings
- Work collaboratively and provide training and mentorship for internal team members across functional groups
Education, Experience and Qualifications
- PhD/MS in immunology, cancer biology, molecular biology or related discipline with 2+ years (PhD) or 5-10 years (MS) experience in an academic or industry setting; immunology or immuno-oncology research preferred (job title will depend on level of experience)
- Technical expertise in primary immune cell isolation, culture, and functional assays
- Demonstrated proficiency with immune-based assays including multi-color flow cytometry, Luminex, MSD, ELISA
- Ability to independently plan and execute experiment with strong analytical and troubleshooting skills
- Experience with genetic engineering of primary immune cells including transposon delivery, viral transduction, CRISPR gene editing, or shRNA modification is desirable
- Competency in cell biology, molecular biology and protein chemistry techniques, including qPCR and western blotting would be highly valued
- Ability to quickly learn, and adapt in a fast paced, rapidly developing environment.
- Self-motivated and can effectively train and mentor other scientists, working in collaborative teams
- Excellent organization and communication skills
Please contact us at opportunities@catamaranbio.com or visit us at www.catamaranbio.com
Catamaran Bio is proud to be an equal opportunity workplace and is an affirmative action employer. We are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.
Company Background
Catamaran Bio is developing novel, off-the-shelf CAR-NK cell therapies designed to treat a broad range of cancers, including solid tumors. Our proprietary capabilities enable us to harness the natural cancer-fighting properties of NK cells and enhance and tailor their effectiveness with the power of synthetic biology and innovative non-viral cell engineering. We are using our TAILWIND™ Platform, an integrated suite of technologies, to specifically address the end-to-end methods of engineering, processing and manufacturing NK cells and rapidly advance our pipeline of CAR-NK cell therapy programs. Catamaran is backed by leading financial and corporate investors, including SV Health Investors, Sofinnova Partners, Lightstone Ventures, Takeda Ventures and Astellas Venture Management.
Job Summary
Catamaran Bio is seeking a highly motivated, experienced, and creative individual with expertise in cancer immunology and cell therapy to be a key driver in our preclinical research efforts to advance our best-in-class Immune Cell Therapies for Oncology. This individual will be responsible for driving in vivo pharmacology studies, through preclinical studies to IND submission. This position is an exciting opportunity to work with talented scientists within a dynamic start-up environment in the Cambridge, MA biotech ecosystem.
Job Responsibilities
- Contribute to the design and implementation of Immuno-oncology preclinical efficacy experiments and PK/PD studies for proof of concept, candidate selection and IND enabling studies
- Run adoptive transfer xenograft mouse models in conjunction with necropsy/tissue/blood collection across multiple projects with delivery of high-quality data
- Prepare primary immune cells for in vivo dosing and perform cell culture with immortalized cell lines
- Develop novel methodologies for ex vivo characterization of engineered NK cells, biomarker assessment, and pharmacodynamic characterization
- Independently and collaboratively design experiments, meticulously execute on bench work, analyze data, troubleshoot and communicate findings
- Represent the in vivo pharmacology function at project team meetings, providing data updates, plans, and critical thinking
- Work collaboratively with internal and external industry and academic teams
- Contribute to report writing and documentation for regulatory and IP filings
- Present findings at internal and external meetings
- Bring enthusiasm and a strong work ethic to the team setting using strong interpersonal skills and collaboration in fast paced environment
- Contribute to building a positive, team-oriented biotech culture
Education, Experience and Qualifications
- BS/MS with 5+ years of relevant academic or industry experience
- Clearly demonstrated experience with xenograft anti-tumor efficacy studies is required
- Preference for experience with immune cell-based therapies such as T cells or NK cells
- Expertise with animal handling, IV, SC and IP dosing, adoptive cell transfer, and tissue harvesting and analysis
- Proficiency in cell culture, passaging and harvesting cells for tumor implant is desired
- Experience with multi-parameter flow cytometry is desired
- Experience with the development and implementation of ex vivo assays to measure functional parameters of engineered human NK cells
- Proficiency in utilizing software such as GraphPad Prism, electronic lab notebooks, Microsoft Office etc. for data analysis and figure generation is required
- Ability to implement applicable regulations around animal care/safety/handling desired
- Demonstrated experience working in cross-functional teams
- Previous experience with IND submission a plus
- Creativity, intellectual, and technical rigor with experience in design, execution, and analysis of experiments
- Strong analytical, troubleshooting and excellent communication skills, highly organized with flawless record keeping and multi-tasking abilities
- Highly collaborative working style, passion for immuno-oncology, and ability to adapt in a fast paced, rapidly developing environment
Please contact us at opportunities@catamaranbio.com or visit us at www.catamaranbio.com
Catamaran Bio is proud to be an equal opportunity workplace and is an affirmative action employer. We are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.
Company Background
Catamaran Bio, a new SV Health Investors biotechnology company, is building a pipeline of effective and safe off-the-shelf cell therapy products for patients with cancer and immune disorders using its integrated engineering and manufacturing TAILWINDTM Platform.
Job Summary
Catamaran is seeking a talented, diligent, curious and collaborative scientist to drive non-viral cell engineering activities and advance our best-in-class Immune Cell Therapies for Oncology and other diseases. This position would play a key role in development of non-viral gene delivery methods to support preclinical research and process development activities. The ideal candidate is a self-motivated, technically competent scientist with deep cell and molecular biology expertise and experience in non-viral gene delivery, who is excited to join a small, fast-paced team with a “can-do” attitude to moving science forward. This position offers an excellent opportunity to work closely with experienced team on cutting-edge technologies and advance your career within growing organization advancing best-in-class Immune Cell Therapies for Oncology.
Job Responsibilities
- Design and develop non-viral cell engineering methods for cell therapy applications
- Optimize non-viral gene delivery protocols to a variety of immune cell types to ensure consistent and reproducible cell modification with minimal impact on cell viability and phenotype.
- Quantify efficiency of gene delivery using transgene analysis and functional assays.
- Collaborate with the cell process team on the optimization of non-viral gene delivery in context of the cell process
- Work closely with the program teams to provide cell engineering solutions for delivery of novel constructs to immune cells
- Be the leader and expert in non-viral gene delivery methods, stay current with emerging methods, and be a resource to management, program teams and scientific team on cell engineering technologies
- Work independently and in close collaboration with all Platform teams, as well as CROs and academic teams
- Lead the development of gene delivery project, and timely deliver on optimization and process conditions
- Independently design, perform and troubleshoot experiments, analyze data, and communicate findings
- Mentor junior scientists in the execution of experiments
- Meticulously maintain records, generate reports, records, and documents for IP and regulatory filings
- Present results at internal and external meetings
- Contribute to building a positive, team-oriented biotech culture
Education, Experience and Qualifications
- PhD/MS Molecular and/or Cell Biology, Biochemistry, Virology, Genetics or related field with 2+ years (PhD) or 10+ years (MS) of industry experience. Title is dependent on experience level
- Demonstrated expertise in non-viral and viral gene delivery methods and extensive molecular biology skills working with nucleic acids
- Experience with electroporation, transduction and other methods of nucleic acid delivery to primary immune cells is required
- Previous experience in gene/cell therapy and cell engineering is preferred
- Independence in driving research activities, including the design, execution, and analysis of experiments
- Ability to quickly learn and adapt within a fast-paced, rapidly developing, startup environment, showing pro-active and team-oriented attitude
- Flawless record keeping and multi-tasking abilities
- Excellent organization and communication skills
Please contact us at opportunities@catamaranbio.com or visit us at www.catamaranbio.com
Catamaran Bio is proud to be an equal opportunity workplace and is an affirmative action employer. We are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.
Job Summary
Catamaran is seeking an experienced, hands-on Research Associate / Senior Research Associate to support Catamaran’s development of an allogeneic NK cell drug product. The successful candidate will be responsible for generating and maintaining stocks of cell lines used for in vitro and in vivo assays, including feeder cells, tumor cell lines, NK cells and genetically modified cells. This work involves cell isolation, expansion, engineering, harvest and cryopreservation. This role will require collaborating extensively with Research and CMC teams. The ideal candidate has relevant experience in cell culture of primary human cells and cell lines, and is excited to join a small, fast-paced team with a “can-do” attitude to drive forward our new cell therapy platform.
Job Responsibilities
- Work closely with the Research and CMC teams to provide cell culture support.
- Perform cell counts and other assays (e.g., mycoplasma testing) as needed to ensure the quality of cell preps.
- Learn and carry out new processes for cell isolation, genetic modification and expansion.
- Work independently and collaboratively as needed to accomplish goals.
- Meticulously generate and maintain records.
- Contribute to building a positive, team-oriented biotech culture.
Education, Experience and Qualifications
- BS or certificate in biology, biotechnology, or equivalent/related disciplines.
- 1-5 years of relevant experience in cell culture in academia or cell therapy industry.
- Motivated, team-oriented.
- Attention to detail and demonstrated ability in multi-tasking and thriving in teams with diverse technical expertise.
- Experience with NK cells a plus.
Please contact us at opportunities@catamaranbio.com or visit us at www.catamaranbio.com
Catamaran Bio is proud to be an equal opportunity workplace and is an affirmative action employer. We are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.
Company Background
Catamaran Bio is developing novel, off-the-shelf CAR-NK cell therapies designed to treat a broad range of cancers, including solid tumors. Our proprietary capabilities enable us to harness the natural cancer-fighting properties of NK cells and enhance and tailor their effectiveness with the power of synthetic biology and innovative non-viral cell engineering. We are using our TAILWIND™ Platform, an integrated suite of technologies, to specifically address the end-to-end methods of engineering, processing and manufacturing NK cells and rapidly advance our pipeline of CAR-NK cell therapy programs. Catamaran is backed by leading financial and corporate investors, including SV Health Investors, Sofinnova Partners, Lightstone Ventures, Takeda Ventures and Astellas Venture Management.
Job Summary
Catamaran Bio is seeking a highly motivated, experienced, and creative individual with expertise in cancer immunology and cell therapy to be a key contributor to our preclinical research efforts to advance our best-in-class Immune Cell Therapies for Oncology. This individual will be responsible for carrying out cell engineering and in vitro studies, providing a critical coordination point across multiple teams to advance the Catamaran pipeline of cell therapies. This position is an exciting opportunity to work with talented scientists within a dynamic start-up environment in the Cambridge, MA biotech ecosystem.
Job Responsibilities
- Isolate immune cells from human tissue sources for ex vivo engineering, characterization, functional assessment, and in vivo adoptive transfer studies
- With supervision, contribute to the design, development, and execution of in vitro and ex vivo cell-based assays using cell lines and human primary cells
- Perform cell and molecular assays, including multi-color flow cytometry, cytotoxicity, and cytokine release
- Perform human cell culture, including transformed cell lines and primary immune cells
- Work with supervisor to design experiments, meticulously execute bench work, troubleshoot assays, analyze data, record data, and communicate findings
- Work collaboratively with internal team members by coordinating across line functions all reagents and supporting material to deliver cell preparations in specified timeline
- Present results at internal meetings
Education, Experience and Qualifications
- BS/MS in immunology, cancer biology, molecular biology or related discipline with 4+ years’ experience in an academic or industry setting; immunology or immuno-oncology research preferred (job title will depend on level of experience)
- Demonstrated familiarity with immune-based assays including flow cytometry, Luminex, MSD, ELISA
- Experience with primary immune cell isolation
- Strong analytical and troubleshooting skills with flawless record keeping and multi-tasking abilities
- Experience with immune cell engineering is a plus
- Competency in cell biology, molecular biology and protein chemistry techniques, including qPCR and western blotting would be highly valued
- Ability to quickly learn, and adapt in a fast paced, rapidly developing environment.
- Self-motivated and able to work both independently and on collaborative teams
- Excellent organization and communication skills
Please contact us at opportunities@catamaranbio.com or visit us at www.catamaranbio.com
Catamaran Bio is proud to be an equal opportunity workplace and is an affirmative action employer. We are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.
